Palabras clave
Cómo citar
Resumen
La oncología oral pediátrica representa un campo complejo y desafiante dentro de la odontología y la oncología pediátricas. Esta breve revisión tiene como objetivo examinar la comprensión actual, los enfoques diagnósticos y las modalidades de tratamiento para las neoplasias malignas orales y maxilofaciales en la población pediátrica. Se hace especial hincapié en la detección precoz, las estrategias de tratamiento multidisciplinario y el tratamiento de las complicaciones relacionadas con el tratamiento. También se discuten los avances recientes en terapias dirigidas y su impacto en las tasas de supervivencia.
Citas
Wani V., Kulkarni A., Pustake B., Takate V., Wani P., Sondhi J.S. Prevalence, complications and dental management of the oral cancer in the pediatric patients. J Cancer Res Ther. 2018; 14 (6): 1407-1.
De Paula D.S., Nóbrega Malta C.E., de Brito W.H., Mota Lemos J.V., Cetira Fillho E.L., Gurgel Costa F.W., Nunes Alves A.P.N., de Barros Silva P.G. Prevalence of malignant neoplastic oral lesions among children and adolescents: A systematic review and meta-analysis. Int J Paediatr Dent. 2021; 31 (4): 504-19.
Narayan V.K., Nitya K., Cruz J.M., Chidambareshwar A., Vasumathi D. (2021). Pediatric tumors of oral and maxillofacial region- clinical diagnosis and management. Issues Develop Medicine Med Res. 2021; l: 21-36.
Dhanuthai K., Banrai M., Limpanaputtajak S. A retrospective study of paediatric oral lesions from Thailand. Int J Paediatr Dent. 2007; 17: 248-53.
Instituto Nacional de Câncer José Alencar Gomes da Silva. Estimativa 2020: Incidência de câncer no Brasil/Instituto Nacional de Câncer José Alencar Gomes da Silva. - Rio de Janeiro. INCA: 2019.
Ha W., Kelloway E., Dost F., Farah C. A retrospective analysis of oral and maxillofacial pathology in an Australian paediatric population. Aust Dent J. 2014; 59: 221-5.
Kumar M., Nanavati R., Modi T.G., Dobariya C. Oral cancer: Etiology and risk factors: A review. J Cancer Res Ther. 2016; 12 (2): 458-63.
Pavan V.H., Fernández de Preliasco V., Ienco M., Benchuya C. Langerhans cell histiocytosis oral lesions in pediatric patients. Acta Odontol Latinoam. 2023; 36 (3): 156-62.
Gartrell J., Pappo A. Recent advances in understanding and managing pediatric rhabdomyosarcoma. F1000Res. 2020; 9: F1000 Faculty Rev-685.
Komatsu Y., Kawai T., Miura S., Takeda Y., Yamada H. Rhabdomyosarcoma in the maxillary gingiva of a child patient. J Surg Case Rep. 2021; 2021 (7): rjab322.
Pinheiro R. dos S., de França T.R., Ferreira Dde C., Ribeiro C.M., Leão J.C., Castro G.F. Human papillomavirus in the oral cavity of children. J Oral Pathol Med. 2011;40 (2): 121-6.
Di Spirito F., Pantaleo G., Di Palo M.P., Amato A., Raimondo A., Amato M. Oral human papillomavirus benign lesions and hpv-related cancer in healthy children: A systematic review. Cancers (Basel). 2023; 15 (4): 1096-101.
Lenoci D., Moresco E., Cavalieri S., Bergamini C., Torchia E., Botta L., Canevari S., Trama A., Licitra L., De Cecco L. Oral cancer in young adults: Incidence, risk factors, prognosis, and molecular biomarkers. Front Oncol. 2024; 14: 1452909.
PDQ Pediatric Treatment Editorial Board. Childhood Oral Cavity Cancer (PDQ®): Patient Version. 2024 Oct 9. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-10.
Garrocho-Rangel A., Márquez-Preciado R., Olguín-Vivar A.I., Ruiz-Rodríguez S., Pozos-Guillén A. Dentist attitudes and responsibilities concerning child sexual abuse. A review and a case report. J Clin Exp Dent. 2015; 7 (3): e428-34.
Tröbs R.B., Mader E., Friedrich T., Bennek J. Oral tumors and tumor-like lesions in infants and children. Pediatr Surg Int. 2003; 19 (9-10): 639-45.
Yuhan B.T., Svider P.F., Mutchnick S., Sheyn A. Benign and malignant oral lesions in children and adolescents: An organized approach to diagnosis and management. Pediatr Clin North Am. 2018; 65 (5): 1033-50.
Khanmohammadi R., Mir F., Baniebrahimi G., Mirzaei H. Oral tumors in children: Diagnosis and management. J Cell Biochem. 2018; 119 (3): 2474-83.
Singh S.B., Sarrami A.H., Gatidis S., Varniab Z.S., Chaudhari A., Daldrup-Link H.E. Applications of artificial intelligence for pediatric cancer imaging. AJR Am J Roentgenol. 2024; 223 (2): e2431076.
Trosman S.J., Krakovitz P.R. Pediatric maxillary and mandibular tumors. Otolaryngol Clin North Am. 2015; 48 (1): 101-19.
George A.P., Markiewicz M.R., Garzon S., Choi D.K. Adolescent and young adult oral maxillofacial tumors: A single-institution case series and literature review. J Adolesc Young Adult Oncol. 2020; 9 (2): 307-12.
Carneiro-Neto J.N., de-Menezes J.D., Moura L.B., Massucato E.M., de-Andrade C.R. Protocols for management of oral complications of chemotherapy and/or radiotherapy for oral cancer: Systematic review and meta-analysis current. Med Oral Patol Oral Cir Bucal. 2017; 22 (1): e15-e23.
Ritwik P. Dental care for patients with childhood cancers. Ochsner J. 2018; 18 (4): 351-7.
Saka-Herrán C., Jané-Salas E., Mari-Roig A., Estrugo-Devesa A., López-López J. Time-to-treatment in oral cancer: Causes and implications for survival. Cancers (Basel). 2021; 13 (6): 1321.
Rana M., Essig H., Eckardt A.M., Tavassol F., Ruecker M., Schramm A., Gellrich N.C. Advances and innovations in computer-assisted head and neck oncologic surgery. J Craniofac Surg. 2012; 23 (1): 272-8.
Gellrich N.C., Ehrenfeld M. Computer assistance in modern craniomaxillofacial surgery. Innov Surg Sci. 2023; 8 (3): 135-6.
Lopez J., Chen Y.H., Eagan A., Fitzgerald C., Woods R., Wong R., Shah J., Ganly I. Surgical management of pediatric salivary malignant tumors-A single-center cohort study. J Surg Oncol. 2022; 126 (8): 1389-95.
Galazka P., Czyzewski K., Marjanska A., Daniluk-Matras I., Styczynski J. Minimally invasive surgery in pediatric oncology: Proposal of guidelines. Anticancer Res. 2019; 39 (11): 5853-9.
Mosel D.D., Bauer R.L., Lynch D.P., Hwang S.T. Oral complications in the treatment of cancer patients. Oral Dis. 2011; 17 (6): 550-9.
Curra M., Gabriel A.F., Ferreira M.B.C., Martins M.A.T., Brunetto A.T., Gregianin L.J., Martins M.D. Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy. Support Care Cancer. 2021; 29 (11): 6243-51
Borges M.M., Malta C.E., Ribeiro R.S., Cetira-Filho E.L., de Moura J.F., Rebouças L.M., Costa F.W., Silva P.B., Mota M.R. Chemotherapy increases the prevalence of radiotherapy-related trismus in head and neck cancer patients: A systematic review and meta-analysis. J Clin Exp Dent. 2024; 16 (4): e503-e515.
Davey A., Pan S., Bryce-Atkinson A., Mandeville H., Janssens G.O., Kelly S.M., Hol M., Tang V., Davies L.S.C., Siop-Europe Radiation Oncology Working Group, Aznar M. The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey. Clin Transl Radiat Oncol. 2023; 43: 100681.
Milgrom S.A., van Luijk P., Pino R., Ronckers C.M., Kremer L.C., Gidley P.W., Grosshans D.R., Laskar S., Okcu M.F., Constine L.S., Paulino A.C. Salivary and dental complications in childhood cancer survivors treated with radiation therapy to the head and neck: A PENTEC comprehensive review. Int J Radiat Oncol Biol Phys. 2024; 119 (2): 467-81.
Stolze J., Vlaanderen K.C.E., Holtbach F.C.E.D., Teepen J.C., Kremer L.C.M., Loonen J.J., van Dulmen-den Broeder E., Heuvel-Eibrink M.M.V.D., Pal H.J.H.V., Versluys B., van der Heiden-van der Loo M., Louwerens M., Raber-Durlacher J.E., Bresters D., Brand H.S. Long-term effects of childhood cancer treatment on dentition and oral health: A dentist survey study from the DCCSS Later 2 Study. Cancers (Basel). 2021; 13 (21): 5264.
Xiao J., Alkhers N., Kopycka-Kedzierawski D.T., Billings R.J., Wu T.T., Castillo D.A., Rasubala L., Malmstrom H., Ren Y., Eliav E. Prenatal oral health care and early childhood caries prevention: Systematic review and meta-analysis. Caries Res. 2019; 53 (4): 411-21.
Vogel J., Both S., Kirk M., Chao H.H., Bagatell R., Li Y., Womer R., Balamuth N., Reilly A., Kurtz G., Lustig R., Tochner Z., Hill-Kayser C. Proton therapy for pediatric head and neck malignancies. Pediatr Blood Cancer. 2018; 65 (2).
Grzeskowiak L.E., Tao B., Knight E., Cohen-Woods S., Chataway T. Adverse events associated with peanut oral immunotherapy in children - A systematic review and meta-analysis. Sci Rep. 2020; 10 (1): 659.
Ebeling M., Derka S., Baudrexl J., Sakkas A., Scheurer M., Wilde F., Schramm A., Pietzka S. Ibuprofen reduces 5-year overall survival of head and neck cancer patients with immunotherapy - A retrospective case-controlled real-world data analysis of 10,000 patients. Anticancer Res. 2024; 44 (1): 313-22.
Taweevisit M., Tantidolthanes W., Keelawat S., Thorner P.S. Paediatric oral pathology in Thailand: A 15-year retrospective review from a medical teaching hospital. Int Dent J. 2018; 68: 227-34.
Pedretti L., Leardini D., Muratore E., Capoferri G., Massa S., Rahman S., Esposito S, Masetti R. Managing the risk of foodborne infections in pediatric patients with cancer: Is the neutropenic diet still an option? Nutrients. 2024; 16 (7): 966.
Jones D.L., Rankin K.V. Management of the oral sequelae of cancer therapy. Tex Dent J. 2012; 129 (5): 461-8.
Mazhari F., Shirazi A.S., Shabzendehdar M. Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta-analysis. Pediatr Blood Cancer. 2019; 66 (3): e27403.
Attinà G., Romano A., Maurizi P., D'Amuri S., Mastrangelo S., Capozza M.A., Triarico S., Ruggiero A. Management of oral mucositis in children with malignant solid tumors. Front Oncol. 2021; 11: 599243.
Braguês R., Marvão M.F., Correia P., Silva R.M. Oral mucositis management in children under cancer treatment: A systematic review. Cancers (Basel). 2024; 16 (8): 1548.
Damascena L.C.L., de Lucena N.N.N., Ribeiro I.L.A., Pereira T.L., Lima-Filho L.M.A., Valença A.M.G. Severe oral mucositis in pediatric cancer patients: Survival analysis and predictive factors. Int J Environ Res Public Health. 2020;17 (4): 1235.
Sung L., Robinson P., Treister N., Baggott T., Gibson P., Tissing W., Wiernikowski J., Brinklow J., Dupuis L.L. Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ Support Palliat Care. 2017; 7 (1): 7-16.
Moursi A.M., Fernandez J.B., Daronch M., Zee L., Jones C.L. Nutrition and oral health considerations in children with special health care needs: Implications for oral health care providers. Pediatr Dent. 2010; 32 (4): 333-42.
Nuño-Íñiguez E.A., Stein K., Caselin-García M.R., Romero-Velarde E., Medina-Jiménez C.P., Troyo-Sanromán R., Sánchez-Zubieta FA. Estrategias de soporte nutricio en pacientes pediátricos con cáncer en México. Rev Med IMSS. 2018; 56 (6): 525-32.
Jicman Stan D., Sârbu M.I., Fotea S., Nechifor A., Bălan G., Anghele M., Vasile C.I., Niculeț E., Sârbu N., Rebegea L.F., Tatu A.L. Oral mucositis induced by chemoradiotherapy in head and neck cancer-a short review about the therapeutic management and the benefits of bee honey. Medicina (Kaunas). 2022; 58 (6): 751-7.
Badr L.K., El Asmar R., Hakim S., Saad R., Merhi R., Zahreddine A., Muwakkit S. The efficacy of honey or olive oil on the severity of oral mucositis and pain compared to placebo (standard care) in children with leukemia receiving intensive chemotherapy: A randomized controlled trial (RCT). J Pediatr Nurs. 2023; 70: e48-e53.
Proc P., Szczepańska J., Skiba A., Zubowska M., Fendler W., Młynarski W. Dental anomalies as late adverse effect among young children treated for cancer. Cancer Res Treat. 2016; 48 (2): 658-67.
Gawade P.L., Hudson M.M., Kaste S.C., Neglia J.P., Constine L.S., Robison L.L., Ness K.K. A systematic review of dental late effects in survivors of childhood cancer. Pediatr Blood Cancer. 2014; 61 (3): 407-16.
Bertacca I., Pegoraro F., Tondo A., Favre C. Targeted treatment of solid tumors in pediatric precision oncology. Front Oncol. 2023; 13: 1176790.
Pham T.D., Teh M.T., Chatzopoulou D., Holmes S., Coulthard P. Artificial intelligence in head and neck cancer: Innovations, applications, and future directions. Curr Oncol. 2024; 31 (9): 5255-90.
Dhanuthai K., Rojanawatsirivej .S, Thosaporn W., et al. Oral cancer: A multicenter study. Med Oral Patol Oral Cir Bucal. 2018; 23: e23-e29.
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Derechos de autor 2025 Saray Aranda-Romo, Arturo Garrocho-Rangel.