Abstract
The antiphospholipid syndrome is a systemic autoimmune disease, orchestrated by multiple autoantibodies directed against phospholipid binding proteins. The disease has diverse clinical manifestations, in which thrombotic events and obstetric complications stand out. Current pharmacological treatment of obstetric antiphospholipid syndrome is oriented towards preventive methods, nonetheless, a considerable number of patients develop clinical manifestations despite optimal pharmacological measures. The current case report deals about a 24-year-old patient with a recent diagnosis of antiphospholipid syndrome who, despite treatment with low dose aspirin, heparin at full therapeutic dose and hydroxychloroquine, eventually develops severe preeclampsia and pregnancy interruption through an emergency c-section.